Department of Microbiology and the College
Jueqi Chen studies innate immune and inflammation signaling pathways that play a crucial role in host defense and inflammatory diseases. Her work has revealed the distinct and redundant functions of multiple ubiquitin E3 ligases in the RIG-I-MAVS pathway, which is essential for detection of invaded RNA viruses such as those responsible for influenza and West Nile fever. In recent years, she has focused on the NLRP3 inflammasome, a unique immune sensor that can recognize diverse signals from both pathogens and environmental danger. Using diverse and complementary experimental approaches, she discovered a novel type of subcellular organelle status that plays an unexpected role in the activation of the NLRP3 inflammasome. This opens up new strategies to therapeutically target a number of human health problems, including infectious diseases, neurodegeneration, and metabolic syndromes.
Chen’s research has been published on Nature, eLife, Cell, and Molecular Cell.
She received a PhD in biomedical science from the University of Texas Southwestern Medical Center and a BS in biotechnology from Zhejiang University in Hangzhou, China. She also was a postdoctoral researcher in molecular biology at the University of Texas Southwestern Medical Center.