Department of Radiation and Cellular Oncology and the College
Jie Zhou is a chemical biologist and protein or antibody engineer. She works at the interface of chemistry and biology and aims to understand how protein post-translational modifications (PTMs) and the enzymes involved contribute to cell signaling in diseases and immune regulation. She also seeks to find out how these PTMs, enzymes, enzymatic reactions, and related cellular processes can be exploited for targeted therapy. To achieve this, she uses cutting-edge techniques from chemical biology, biochemistry, protein engineering, synthetic biology, and informatics.
Her research has been published in the Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, Biochemistry, Journal of the American Chemical Society, Molecular Therapy, CHEM, and Angewandte chemie.
Zhou received a BS in chemistry from Nanjing University, in China, followed by a PhD in chemistry at Brandeis University, where she was a Howard Hughes Medical Institute International Graduate Student Research Fellow. Most recently, she was a postdoctoral researcher in pharmaceutical chemistry at the University of California, San Francisco, supported by a Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship.