Department of Pathology and the College
Andrew Koh studies how immune cells acquire flexibility in fate and function to respond to ever-changing pathogens and cancers while remaining tolerant to self. A major focus of his research is to understand how epithelial cells of the thymus express genes restricted to other lineages (e.g., insulin) to promote tolerance against harmful self-reactive T cells and prevent autoimmunity (e.g., diabetes). He also investigates how T cells acquire competence for so many diverse effector functions and how this plasticity relates to leukemogenesis. Koh employs a broad, interdisciplinary approach with particular emphasis on developing technology that interrogates chromatin states and gene network dynamics at single-cell resolution. By explaining how cellular plasticity is programmed in development and dysregulated in disease, he aims to discover novel therapeutic avenues for human disorders.
Koh’s work has been published in Nature Immunology, Proceedings of the National Academy of Sciences, and Journal of Immunology. He was a Leukemia & Lymphoma Society Fellow and twice received the Award for Excellence and Distinction in Teaching at Harvard College, among other honors.
Koh earned a PhD from Harvard University and a BS from the University of California, Los Angeles. Most recently, he was a postdoctoral fellow at Stanford University.