Department of Neurobiology
Paschalis Kratsios’s research builds on and expands knowledge of the molecular principles governing motor neuron diversity and motor circuit assembly. It focuses on how motor neuron diversity is generated during development and maintained throughout life, as well as the molecular mechanisms that ensure synapse formation and specificity within the motor circuit, and whether there are evolutionarily conserved principles behind motor circuit assembly. To address these ideas, his laboratory harnesses the specific strengths of two model organisms. It uses the nematode Caenorhabditis elegans as a gene discovery tool and then aims to translate these findings to the vertebrate nervous system, using the mouse Mus musculus as a model.
His work has been published in the Journal of Clinical Investigation, Circulation Research, Nature Neuroscience, Current Biology, eLIFE, and Science. Among his many awards and prizes is the National Institutes of Health’s Pathway to Independence Award. He is also a member of the Society for Neuroscience, the New York Academy of Sciences, and the Genetics Society of America.
Kratsios received his PhD in molecular biology and biomedicine from the European Molecular Biology Laboratory. He was a postdoctoral scholar with the Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biophysics at Columbia University.