Department of Medicine and the College
Luis Barreiro has pioneered the use of population genomic data to characterize the genetic basis of inter-individual differences in immune response to infectious agents. His work has demonstrated that natural selection has significantly contributed to recent human evolution; that past selective events impact present-day susceptibility to disease; and that functional genomic approaches for mapping gene expression QTL (quantitative trait locus) can be used to reveal new genetic loci associated with susceptibility to infectious disease, notably tuberculosis. Recently, his laboratory characterized the genetic basis of population differences in immune regulation and the role of variation in social status on immune function. His work has also considerably advanced the basic science of gene regulation by demonstrating how innate immune cells actively remodel their epigenome.
Barreiro was recognized by the journal Cell as one of the “40 under 40” most promising investigators in the world in 2014. He holds undergraduate and master’s degrees in biotechnology from Lusófona University in Lisbon, and a PhD in human population genetics from the Université Paris Diderot. Most recently, he was a faculty member at the Université de Montréal and a researcher at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Center.