Department of Pathology and the College
Daria Esterházy studies interactions of the diet and microbiome with the endocrine and immunological functions of the digestive system in health and disease, from the biochemical to the organismal level. She is interested in how immune homeostasis is maintained in the digestive system, failure of which can lead to chronic infections, food allergies, inflammatory bowel diseases, autoimmune diseases, and cancer. In particular, she is exploring the possibility that the existence of multiple immunologically distinct niches support striking the balance between tolerance and immunity, and is also investigating how these compartments are created by dietary, commensal colonization, and infection history in the course of a lifetime.
She received her BA and MSci in biochemistry from the University of Cambridge, and obtained her PhD from ETH Zurich in Switzerland, where she studied the control of pancreatic beta cell function by cell surface proteases. She then embarked upon postdoctoral studies at the University of Texas Southwestern Medical Center, where she investigated intestinal postprandial hormones. Most recently, she was a postdoctoral fellow and research associate at the Rockefeller University, where she studied how peripheral regulatory T cells that recognize dietary antigens are generated.