Alexander Ruthenburg

Neubauer Family Assistant Professor
Department of Molecular Genetics & Cell Biology and the College

The unifying focus for Alexander Ruthenburg’s research is the elucidation of molecular mechanisms underlying genome management using the toolkits of biochemistry and chemical and structural biology, in particular, how posttranslational modifications and noncoding RNA can control chromatin structure.

His research spans several traditional disciplines, ranging from discovery biochemistry and chemical biology to mechanistic characterization with biophysical methods coupled with x-ray structure to address fundamental questions in chromatin biology.

Ruthenburg was recently named Chicago Biomedical Consortium Junior Investigator and Irvington Institute Fellow of the Cancer Research Institute. He is coauthor of several recent publications, including “Multivalent Interactions Interpret the Histone Code at the Nucleosome Level” and “Multivalent Interactions of the MLL1 PHD Fingers and CXXC Domain Control Recruitment and Stable Binding of MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis.”

Ruthenburg received a PhD in chemistry from Harvard University and a BA (with distinction) in chemistry from Carleton College.

Ruthenburg joined the University of Chicago faculty in 2010.

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