Department of Radiology
Kenneth Bader’s research interests include histotripsy, a novel form of therapeutic ultrasound that employs the mechanical action of oscillating cavitation bubbles to ablate thrombi. His preliminary data demonstrate that the thrombolytic recombinant tissue plasminogen activator acts synergistically with histotripsy pulses to provide enhanced thrombolysis in a highly retracted venous clot in vitro. Further studies will elucidate the efficacy and potential risks of histotripsy to ablate venous thrombosis and provide new information to assist the development of targeted ablation methods to improve thrombolysis in the treatment of currently intractable deep vein thrombosis. His data have also shown that passive cavitation imaging (PCI) is significantly more accurate and sensitive to mechanical ablation than B-mode ultrasound imaging.
His research has been published in Physics in Medicine & Biology, Ultrasound in Medicine & Biology, and the Journal of Thrombosis and Thrombolysis.
Bader earned a PhD in physics from the University of Mississippi and completed a postdoctoral fellowship at the University of Cincinnati’s Department of Internal Medicine.