Department of Biochemistry and Molecular Biology and the College
Jingyi Fei’s research has been centered on ribonucleic acid (RNA) biology using cutting-edge single-molecule and cell-imaging techniques, with special emphasis on the mechanistic studies of gene expression and regulation. Her doctoral work focused on studying prokaryotic translation with an in vitro reconstituted system using single-molecule fluorescence resonance energy transfer (smFRET). More recently, she has been taking on a new direction, focusing on gene regulation by small noncoding RNAs (sRNAs). Using a super-resolution imaging and analysis approach, she was able to directly observe the sRNA-mediated messenger RNA (mRNA) degradation and obtain quantitative and localization information, which allowed for the establishment of a kinetic model in vivo.
Her research findings have appeared in Science, Proceedings of the National Academy of Sciences of the United States of America, Molecular Cell, Nature Structural & Molecular Biology, Biophysical Journal, and Journal of the American Chemical Society.
Fei earned a BS with honors in chemical physics from the University of Science and Technology of China. She holds a PhD with honors in biophysical chemistry from Columbia University and received the Hammett Award from its Department of Chemistry for excellence in studies and research. Most recently she was a postdoctoral fellow at the Center for the Physics of Living Cells at the University of Illinois.