Department of Chemistry and the College
The practice of chemical synthesis has matured to a discipline capable of providing compounds of amazing complexity for biological, medical, and materials research, but the efficiency by which molecules are prepared, and thus the speed at which they are applied toward societal problems, is limited by a number of factors. Of these, extended synthetic sequences, isolation of intermediates, and low catalyst activity/selectivity are particularly notable. Jared Lewis is currently focusing on identifying solutions to these problems through the development of new catalyst systems for a variety of key chemical transformations. Small molecule transition metal catalysts, enzymes, and artificial metalloenzymes are being explored toward this end.
Lewis was honored with the NIH Pathways to Independence Award in 2010 and the Searle Scholar Award in 2011. He has coauthored many publications, including “Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates” and “Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines.”
Lewis earned his PhD in chemistry from the University of California, Berkeley, and a BS in chemistry from the University of Illinois at Urbana-Champaign. He was also a National Institutes of Health Postdoctoral Fellow at California Institute of Technology.
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