Department of Radiation and Cellular Oncology
Sean Pitroda’s research focus has involved the development of pathway-driven bioinformatics tools to explore transcriptional patterns with relevance to human cancers. Through these investigations, he discovered novel therapy predictive and prognostic gene signatures with relevance to human lung, breast, colon, and brain cancers. The results of these studies were published in Science Translational Medicine, Proceedings of the National Academy of Sciences of the United States of America, Oncogene, and Cancer Research.
Pitroda has since expanded this effort to explore oncogenic pathways mediating resistance to genotoxic therapies, including radiation and chemotherapy, metastasis, and immune evasion. His investigations also work toward identifying the first mechanism for the biological basis of oligometastasis, a clinically distinct subset of metastasis characterized by a limited number of metastases that are potentially curable with localized therapies.
Pitroda earned an MD from the University of Chicago Pritzker School of Medicine. He completed his internship and residency at the University of Chicago, as well as an externship at Memorial Sloan Kettering Cancer Center.